HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → HCID 19902813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 19902836 | HCID 19902836 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 19902813 | HCID 19902813 | — |
Reaction Steps
An ethereal solution of diazomethane (excess) is added to a stirred suspension of ethyl 1,6-dihydro-2-acetyl-6-oxonicotinate (2.20 g, 10.5 mmol) in 10 ml of ether. The ether and excess diazomethane are removed under vacuum, and the crude product is purified by column chromatography, eluting with 30% ethyl acetate/hexane to give ethyl 2-acetyl-6-methoxynicotinate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05098462 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-16adb3c351fb40aebf71f35691f87e82 |
| Source note | uspto-grants-1992_03 |