Acetic Anhydride → Furo[3,4-b]pyridine-5,7-dione, 3-ethyl-

HRID 2372186Notes

Reaction equation

HRID 2372186 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[C:6]([C:9]([OH:11])=O)=[N:7][CH:8]=1)[CH3:2].C(OC(=O)C)(=O)C>>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:12](=[O:13])[O:14][C:9](=[O:11])[C:6]2=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 1136065-Ethyl-2,3-pyridinedicarboxylic acid

Product 1

HCID 10921053Furo[3,4-b]pyridine-5,7-dione, 3-ethyl-

Procedure

A mixture of the above carboxylic acid (3.0 g, 15.37 mmol) and acetic anhydride (15 ml) is heated until the acid is dissolved. The mixture is then concentrated under vacuum, and the residue is dissolved in ether, stirred, filtered, concentrated and dried to give 5-ethyl-2,3-pyridinedicarboxylic anhydride.

Workup

  1. temperatureis heated until the acid
  2. dissolutionis dissolved
  3. concentrationThe mixture is then concentrated under vacuum
  4. dissolutionthe residue is dissolved in ether
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customdried

Sources & evidence

ORD record
ord-d82fc0977ebc4fc68d0126da10d28e86
Source dataset
uspto-grants-1992_03
Patent number
US05098462

Reaction notes

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