HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Acetyl-1,3-thiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 19902814 | HCID 19902814 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-Acetyl-1,3-thiazole-5-carboxylic acid | HCID 19902843 | — |
Reaction Steps
Following the procedure of Example 28, methyl 4-ethyl-5-thiazolecarboxylate is reacted with NBS and AIBN to give methyl 4-(1-bromoethyl)-5-thiazolecarboxylate, which is then reacted with sodium bicarbonate, or alteratively with potassium carbonate, and DMSO and the resulting methyl 4-acetyl-5-thiazolecarboxylate is treated with lithium hydroxide monohydrate to yield 4-acetyl-5-thiazolecarboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05098462 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-64563399cd4646c4ac9015d47877f142 |
| Source note | uspto-grants-1992_03 |