4-Phenylsemicarbazide → HCID 178467405, compound

HRID 2372200Notes

Reaction equation

HRID 2372200 reaction equation
[C:1]([C:4]1[N:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)(=[O:3])[CH3:2].[C:13]1([NH:19][C:20](=[O:23])[NH:21][NH2:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CO>[C:13]1([NH:19][C:20](=[O:23])[NH:21][N:22]=[C:6]([OH:8])[C:5]2[CH:9]=[CH:10][CH:11]=[N:12][C:4]=2[C:1](=[O:3])[CH3:2])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 108374-PhenylsemicarbazideHCID 101762782-Acetyl-3-pyridinecarboxylic acid

Product 1

HCID 178467405HCID 178467405, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 2-acetylnicotinic acid (0.40 g, 2.4 mmol) in 7 ml of methanol is added a solution of 4-phenylsemicarbazide (0.37 g, 2.4 mmol) in 5 ml of methanol. The mixture is stirred at RT overnight, after which the solid precipitate is collected by filtration, washed with ethanol and dried to give 2-acetyl-nicotinic acid 4-phenylsemicarbazone, m.p. 174° (dec.) (compound 1, Table A).

Workup

  1. filtrationafter which the solid precipitate is collected by filtration
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-1a713bd600724e7d97fdf2cabae68bb3
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

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