Acetic Anhydride → Furo[3,4-b]pyridine-5,7-dione, 3-ethyl-

HRID 2372220Notes

Reaction equation

HRID 2372220 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[C:6]([C:9]([OH:11])=O)=[N:7][CH:8]=1)[CH3:2].C(OC(=O)C)(=O)C>>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:12](=[O:13])[O:14][C:9](=[O:11])[C:6]2=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 1136065-Ethyl-2,3-pyridinedicarboxylic acid

Product 1

HCID 10921053Furo[3,4-b]pyridine-5,7-dione, 3-ethyl-

Procedure

A mixture of the above carboxylic acid (3.0 g, 15.37 mmol) and acetic anhydride (15 ml) is heated until the acid is dissolved. The mixture is then concentrated under vacuum, and the residue is dissolved in ether, stirred, filtered, concentrated and dried to give 5-ethyl-2,3-pyridinedicarboxylic anhydride.

Workup

  1. temperatureis heated until the acid
  2. dissolutionis dissolved
  3. concentrationThe mixture is then concentrated under vacuum
  4. dissolutionthe residue is dissolved in ether
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customdried

Sources & evidence

ORD record
ord-05a87fea89d04b14afe58b3de8644bda
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

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