HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 3-Acetyl-1,2-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 19902851 | HCID 19902851 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-Acetyl-1,2-thiazole-4-carboxylic acid | HCID 22908682 | — |
Reaction Steps
Following generally the procedure of Example 28, ethyl 3-ethyl-4-isothiazolecarboxylate is reacted with NBS and benzoyl peroxide to give ethyl 3-(1-bromoethyl)-4-isothiazolecarboxylate, which is then reacted with sodium bicarbonate and DMSO and the resulting ethyl 3-acetyl-4-isothiazolecarboxy-late is treated with lithium hydroxide monohydrate to yield 3-acetyl-4-iso-thiazole-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05098466 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-fff06769f20c4a829271a952cc71cb46 |
| Source note | uspto-grants-1992_03 |