Oxygen → 120051-39-0

Participants

Reaction Steps

6β,14α-dihydroxy-4-androstene-3,17-dione (50 g) thus prepared in the above-mentioned manner was dissolved in 1 liter of chloroform and transferred to a glass sealable vessel; after blowing oxygen therein, the vessel was sealed and allowed to stand for 4 hours under sunlight. Thereafter, the chloroform was removed by evaporation at 40° C. After the evaporation, the resultant residue was analyzed by thin layer chromatography and a spot for 14α-hydroxy-4-androstene-3,6,17-trione only was confirmed. According to this method, 49.2 g of 14α-hydroxy-4-androstene-3,6,17-trione was obtained. The yield was 98.4%.

Provenance & Evidence