反应详情

温度

50 °C

0.66 g (2 mmol) of 2-(2-trifluoromethylhexyl)-5-(4-hydroxyphenyl)-1, 3, 4-thiadiazole was added to pyridine, 0.50 g (2,5 mmol) of undecanoic acid chloride was dripped while the mixture was cooled, and they were stirred at 50° C. for two hours. After the reaction was completed, water was added, ether extraction was performed, the solution was dried, and the solvent thereof was removed. Then, the solution was refined by column chromatography (toluene: ethyl acetate=6:1) and recrystallization (ethanol), and 0.72 g of a desired material was obtained. ##STR31##

1. temperaturewas cooled
2. extractionether extraction
3. customthe solution was dried
4. customthe solvent thereof was removed
5. customThen, the solution was refined by column chromatography (toluene: ethyl acetate=6:1) and recrystallization (ethanol)