HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-(3-Fluoro-4-hydroxyphenyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 3'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid | HCID 1203166 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(3-Fluoro-4-hydroxyphenyl)benzoic acid | HCID 836139 | 92.2% |
Reaction Steps
To 42 g (0.17 mol) of the above 3'-fluoro-4'-methoxybiphenyl-4-carboxylic acid were added 1.7 l of acetic acid and 300 ml of 48% hydrogen bromide solution, which was refluxed for 20 hours, poured into 3.5 l of water and air cooled. The precipitated crystal was filtered to obtain 36.4 g (yield: 92%) of 3'-fluoro-4'-hydroxybiphenyl-4-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05098602 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-6076c2dec0714be3891e41252d92af29 |
| Source note | uspto-grants-1992_03 |