HCID 14820094, compound → HCID 14820145, compound

HRID 2372275Notes

Reaction equation

HRID 2372275 reaction equation
[C:1]([C:4]1[C:17]([OH:18])=[CH:16][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[C:6]([CH2:19][CH:20]=[CH2:21])[CH:5]=1)(=[O:3])[CH3:2].[H][H]>[Pd].C(O)C>[C:1]([C:4]1[C:17]([OH:18])=[CH:16][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[C:6]([CH2:19][CH2:20][CH3:21])[CH:5]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 14820094HCID 14820094, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14820145HCID 14820145, compoundYield 101.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The compound of Example 131 (1.46 g) was added to 150 ml of ethanol and hydrogenated in the presence of 1.5 g of 5% palladium on carbon. After the theoretical amount of hydrogen was taken up, the reaction wad discontinued, the reaction mixture was filtered. The filtrate was concentrated in vacuo and provided 1.49 g of the desired title product, m.p. =106° C.

Workup

  1. filtrationthe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-d1fcfa92fad44a109c2f079a1e1c0ade
Source dataset
uspto-grants-1992_03
Patent number
US05098613

Reaction notes

Loading…