Acetyl chloride → HCID 14820121, compound

HRID 2372277Notes

Reaction equation

HRID 2372277 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[C:13]([CH2:14][CH3:15])=[CH:12][C:11]([C:16](=[O:18])[CH3:17])=[C:10]([OH:19])[CH:9]=1.[C:20](Cl)(=[O:22])[CH3:21]>N1C=CC=CC=1>[C:16]([C:11]1[C:10]([OH:19])=[CH:9][C:8]([O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:20](=[O:22])[CH3:21])=[C:13]([CH2:14][CH3:15])[CH:12]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 14820120HCID 14820120, compound

Product 1

HCID 14820121HCID 14820121, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a manner analogous to that taught in Example 77, 265 mg of the amine from Example 137 was acylated with acetyl chloride and pyridine to provide 158 mg of the desired title product, m.p. =115°-116° C.

Sources & evidence

ORD record
ord-e664e9ee65a7497780779601cbf56058
Source dataset
uspto-grants-1992_03
Patent number
US05098613

Reaction notes

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