Chloroacetone → HCID 19902987, compound

Participants

Reaction Steps

In operations carried out in a manner similar to that described in Example I, 1-(3-amino-3-oxopropyl)imidazol-2-thiol was reacted first with chloroacetone in the presence of triethylamine to obtain 1-(3-amino-3-oxopropyl)-3-methyl-2[(2-oxopropyl)thio]-1H-imidazole, which then was reacted with methyl trifluoromethanesulfonate to obtain 1-(3-amino-3-oxopropyl)-3-methyl-2[(2-oxopropyl)thio]-1H-imidazolium trifluoromethanesulfonate which in turn was passed through a Dowex 1(Cl-) ion exchange column to obtain 1-(3-amino-3-oxopropyl)-3-methyl-2[(2-oxopropyl)thio]-1H-imidazolium chloride, m.p. 124°-125° C.

Provenance & Evidence