4-Bromoanisole → LABOTEST-BB LT00239243

HRID 2372307Notes

Reaction equation

HRID 2372307 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.[C:14](Cl)([CH3:17])([CH3:16])[CH3:15]>O>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:7]=1

Participants

5

Reactant 3

HCID 77304-BromoanisoleHCID 10486tert-BUTYL CHLORIDEHCID 6451240Aluminum(III) Chloride

Product 1

HCID 3733898LABOTEST-BB LT00239243

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.10 g (22.6 mmol) of aluminum chloride are added all at once to a mixture of 63.5 g (339 mmol) of p-bromoanisole and 31.4 g (330 mmol) of tert.butyl chloride. The mixture is stirred at ambient temperature until the evolution of gas ceases (about 15 minutes). The mixture is then heated at 80° C. for 15 minutes and poured into ice. 300 ml of water are added and the mixture is extracted with ether.

Workup

  1. temperatureThe mixture is then heated at 80° C. for 15 minutes
  2. additionpoured into ice
  3. extractionthe mixture is extracted with ether

Sources & evidence

ORD record
ord-b01f31dd45f0445d8ef6d72e819fd2a8
Source dataset
uspto-grants-1992_03
Patent number
US05098895

Reaction notes

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