Sodium Carbonate → HCID 19903217, compound

HRID 2372317Notes

Reaction equation

HRID 2372317 reaction equation
C(=O)([O-])[O-:2].[Na+].[Na+].Cl.[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[C:19](=[O:20])[CH2:18][CH2:17][C:16]2=[O:21])[CH2:10][CH2:9]1.Cl[C:23]1[CH:28]=[CH:27][N:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[N:24]=1>O>[OH2:2].[F:30][C:29]([F:32])([F:31])[C:25]1[N:26]=[C:27]([N:8]2[CH2:9][CH2:10][CH:11]([CH2:14][N:15]3[C:19](=[O:20])[CH2:18][CH2:17][C:16]3=[O:21])[CH2:12][CH2:13]2)[CH:28]=[CH:23][N:24]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 152943694-Chloro-2-(trifluoromethyl)pyrimidineHCID 21694998HCID 21694998, compound

Product 1

HCID 19903217HCID 19903217, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium carbonate (30 g, 0.28 mol) was added to a solution of XVIII in water (250 mL). The solution was then vigorously stirred with ice bath cooling as 4-chloro-2-(trifluoromethyl)-pyrimidine (IV, 16.06 g, 88 mmol) was added. The mixture warmed to room temperature over a 24 hr period, and the desired product was formed as a white precipitate (21.76 g, 73.3%, mp: 144°-145° C.) which was collected, washed with water, and dried.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-432084cf95c6427d9659556eeadd02a1
Source dataset
uspto-grants-1992_03
Patent number
US05098904

Reaction notes

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