Sodium Carbonate → HCID 53886506, compound

HRID 2372318Notes

Reaction equation

HRID 2372318 reaction equation
Cl.O.[NH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1.C(=O)([O-])[O-].[Na+].[Na+].Cl[C:17]1[CH:22]=[CH:21][N:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=1>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:19]1[N:20]=[C:21]([N:3]2[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]2)[CH:22]=[CH:17][N:18]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 2723901PiperonylamineHCID 152943694-Chloro-2-(trifluoromethyl)pyrimidine

Product 1

HCID 53886506HCID 53886506, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Piperidone monohydrate hydrochloride (XXVII, 3.37 g, 21.9 mmol) was added to a stirred mixture of methylene chloride (50 mL) and saturated aqueous sodium carbonate (8 mL). 4-Chloro-2-(trifluoromethyl)pyrimidine (IV, 4.0 g, 21.9 mmol) was then added to the mixture which was then stirred for 2 days. The organic layer was separated, dried over magnesium sulfate, and concentrated in vacuo to give the product as a white solid (4.9 g, 92%) which was used in the next step without further purification.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4ab15d61671247ab94e1eb3559a7ea7d
Source dataset
uspto-grants-1992_03
Patent number
US05098904

Reaction notes

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