HCID 14497613, compound → HCID 14497612, compound

HRID 2372331Notes

Reaction equation

HRID 2372331 reaction equation
[Br:1][CH2:2]/[C:3](/[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)=[CH:4]/[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11]>C(O)C>[Br:1][CH2:2]/[C:3](/[C:12]1[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=1)=[CH:4]\[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11]

Participants

3

Reactant 1

HCID 14497613HCID 14497613, compound

Product 1

HCID 14497612HCID 14497612, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

77.2 g of E-1-bromo-2-(4-fluorophenyl)-3-(2-chlorophenyl)-prop-2-ene are heated at 180° C. for one hour. The reaction mixture is cooled to room temperature and 200 ml of ethanol are added. Thereafter, 10 g of active carbon are added and the mixture is heated to 50° C. and filtered while hot. 26.9 g (35%) of Z-1-bromo-2-(4-fluorophenyl)-3-(2-chlorophenyl)-prop-2-ene of melting point 73°-75° C. are obtained from ethanol.

Workup

  1. additionThereafter, 10 g of active carbon are added
  2. temperaturethe mixture is heated to 50° C.
  3. filtrationfiltered while hot

Sources & evidence

ORD record
ord-6c6985d834294856a3095b3dcfd2cde5
Source dataset
uspto-grants-1992_03
Patent number
US05098917

Reaction notes

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