4-(aminomethyl)-N,N-dimethylaniline dihydrochloride → HCID 13853869, compound

HRID 2372339Notes

Reaction equation

HRID 2372339 reaction equation
Cl.Cl.[CH3:3][N:4]([CH3:13])[C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1.[Cl:14][C:15]1[C:16](=[O:26])[N:17]([C:22]([CH3:25])([CH3:24])[CH3:23])[N:18]=[CH:19][C:20]=1Cl>>[Cl:14][C:15]1[C:16](=[O:26])[N:17]([C:22]([CH3:24])([CH3:23])[CH3:25])[N:18]=[CH:19][C:20]=1[NH:10][CH2:9][C:8]1[CH:11]=[CH:12][C:5]([N:4]([CH3:13])[CH3:3])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27346334-(aminomethyl)-N,N-dimethylaniline dihydrochlorideHCID 27822252-Tert-butyl-4,5-dichloro-2,3-dihydropyridazin-3-one

Product 1

HCID 13853869HCID 13853869, compound

Procedure

The compounds as identified in Table 9 were prepared in the synthetic manner and after-treatment similar to those in Example 2 except that the benzylamine dihydrochlorides with Y1, Y2, Y3 and R3 as identified in Table 9 were used instead of the starting 4-dimethylaminobenzylamine dihydrochloride used in Example 2, and the 4,5-di(chloro or bromo)-2-alkyl-3(2H)pyridazinones with R1 and R2 as identified in Table 8 were used instead of the starting 4,5-dichloro-2-t-butyl-3(2H)pyridazinone. In the NMR data, only the characteristic absorptions are given in Table 9.

Workup

  1. customwere prepared in the synthetic manner

Sources & evidence

ORD record
ord-f2312b8eb4804b15b242de19ac31b7ed
Source dataset
uspto-grants-1992_03
Patent number
US05098900

Reaction notes

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