Hydrochloric Acid → HCID 13853899, compound

Participants

Reaction Conditions

Reaction Steps

A mixture comprising 2.2 g of 4-methoxybenzylamine, 0.30 g of 4-methyl-5-chloro-2-i-propyl-3(2H)pyridazinone, 1.34 g of sodium hydrogencarbonate, 0.23 g of potassium carbonate and 5 ml of tri-n-propylamine, was heated at 150° C. for 18 hours. The reaction mixture was acidified with a 10% hydrochloric acid aqueous solution, and extracted with 60 ml of benzene. The benzene layer was washed with water, and dried over anhydrous sodium sulfate, and then the solvent was distilled off to obtain an oily substance. This substance was crystallized from 5 ml of ethyl ether to obtain 40 mg of the above identified compound.

Provenance & Evidence