1-Benzyloxycarbonyl-3-(1-tert-butoxycarbonylaminoethyl)pyrrolidine → tert-butyl N-[1-(pyrrolidin-3-yl)ethyl]carbamate

Participants

Reaction Steps

640 mg of 1-benzyloxycarbonyl-3-(1-tert-butoxycarbonylaminoethyl)pyrrolidine isomer (P-2A) and 300 mg of 5% Pd-C (50% wet) were added to 20 ml of ethanol and catalytic reduction was carried out at room temperature under 3 atm. for 3 h. Then, the catalyst was filtered off and ethanol was distilled off to obtain 390 mg of the desired compound (P-3A) in the form of a colorless, viscous oil.

Provenance & Evidence