HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2372360Generated: October 31, 2026
Thionyl Chloride → 5-(4-Methoxyphenyl)-4-phenyl-1,2,3-thiadiazole
https://huagongshe.com/reaction/2372360
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Ethyl [2-(4-methoxyphenyl)-1-phenylethylidene]hydrazine carboxylate | HCID 54026400 | — |
| Product | 5-(4-Methoxyphenyl)-4-phenyl-1,2,3-thiadiazole | HCID 13427180 | 82.3% |
Reaction Steps
The acylhydrazone 9 (4.6 g, 14.8 mol), was added to SOCl2 (25 ml) at 0° C. The reaction was stirred to 60° C. and was complete (by TLC) after 1.5 hour. SOCl2 was evaporated under reduced pressure and the crude oil was chromatographed on SiO2 (150 g), eluting with CH2Cl2 to afford 8 (3.25 g, 82.3%), m.p. 56.5°-58° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05098918 |
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| Source dataset | uspto-grants-1992_03 |
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| ORD ID | ord-4e2841d8e3384d26ad368560fb698d57 |
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| Source note | uspto-grants-1992_03 |
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