Thionyl Chloride → HCID 13427181, compound

Participants

Reaction Steps

Acylhydrazone 15 (4.32 g, 11.6 mmol) was added to SOCl2 (50 ml) at 0° C. The reaction was allowed to warm to room temperature. The reaction was complete (by TLC) after 3 hours. SOCl2 was removed under reduced pressure and the crude brown oil was chromatographed on 350 g SIO2, eluting with 4:1, CH2Cl2 :Hexane to afford 13 (1.7 g, 44.7%), m.p. 90-91.5.

Provenance & Evidence