Tin tetrachloride → 1,2-Di-2-thienylethanone

Participants

Reaction Steps

SnCl4 (1.01 g, 3.94 mmol) in CH2Cl2 (5 ml) was added to 2-thiophenylacetyl chloride (6.33 g, 39.4 mmol) and thiopene (3.32 g, 39.4 mmol) in CH2Cl2 (300 ml) at room temperature. The reaction was complete (by TLC) after 3 hours. The solution was poured over a 10% aqueous HCl/ice slurry. The organic layer was separated, washed twice with H2O and dried over MgSO4. The solvent was removed under reduced pressure. The crude oil was chromatographed on SiO2 (300 g), eluting with Hexane/CH2Cl2, 1/1 to afford 30 (3.3 g, 40.5%).

Provenance & Evidence