Phosphorus sulfide (P2S5) → HCID 19903350, compound

HRID 2372374Notes

Reaction equation

HRID 2372374 reaction equation
[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=O)[CH:3]1[C:8]([O:10][CH2:11][CH3:12])=[O:9].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:14]>C1C=CC=CC=1>[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=[S:14])[CH:3]1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 19903390HCID 19903390, compound

Product 1

HCID 19903350HCID 19903350, compoundYield 146.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
50 °C

Procedure

2.5 g of ethyl 4-methyl-2-oxopyrrolidine-3-carboxylate and 3.4 g of phosphorus pentasulfide were added to 50 ml of benzene and stirred at 50° C. for 1 hour. After cooling, the insoluble matters were filtered off and the filtrate was concentrated. The residue was purified by silica gel chromatography to thereby give 2.1 g of the title compound as an oily product.

Workup

  1. temperatureAfter cooling
  2. filtrationthe insoluble matters were filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-ecc0947e65be4fd4b37b52f5debd7034
Source dataset
uspto-grants-1992_03
Patent number
US05098919

Reaction notes

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