Sodium Acetate → HCID 85114049, compound

HRID 2372376Notes

Reaction equation

HRID 2372376 reaction equation
[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=[S:7])[CH:3]1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9].C([O-])(=O)C.[Na+].[CH2:19]([O:21][C:22](=[O:28])[CH2:23][C:24]([CH2:26]Br)=O)[CH3:20]>C(O)C>[CH:11]([O:10][C:8]([C:3]1[CH:2]([CH3:1])[CH2:6][N:5]2[C:24](=[CH:23][C:22]([O:21][CH2:19][CH3:20])=[O:28])[CH2:26][S:7][C:4]=12)=[O:9])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 575284Ethyl 4-bromo-3-oxobutanoateHCID 10465433Isopropyl 4-Methyl-2-thioxopyrrolidine-3-carboxylate

Product 1

HCID 85114049HCID 85114049, compoundYield 43.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.9 g of isopropyl 4-methyl-2-thioxopyrrolidine-3-carboxylate was dissolved in 50 ml of ethanol and 3.0 g of anhydrous sodium acetate and 7.7 g of 4-bromoacetoacetic acid ethyl ester were added thereto. The obtained mixture was stirred at room temperature for 3.5 hours. The crystals thus precipitated were collected by filtration, washed with water and dried. After recrystallization from a mixture of chloroform and ethanol, 3.3 g of the title compound was obtained.

Workup

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization
  6. additionfrom a mixture of chloroform and ethanol

Sources & evidence

ORD record
ord-4c9c4bb3448c45f98ce1ec299dad1ffc
Source dataset
uspto-grants-1992_03
Patent number
US05098919

Reaction notes

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