Dimethylamine → HCID 57271419, compound

HRID 2372382Notes

Reaction equation

HRID 2372382 reaction equation
[CH:1]([O:4][C:5]([C:7]1[CH:8]([CH3:28])[CH2:9][N:10]2[C:14](=[CH:15][C:16]([O:18]C3C=CC([N+]([O-])=O)=CC=3)=O)[CH2:13][S:12][C:11]=12)=[O:6])([CH3:3])[CH3:2].[CH3:29][NH:30][CH3:31]>O>[CH3:29][N:30]([CH3:31])[C:16](=[O:18])[CH:15]=[C:14]1[CH2:13][S:12][C:11]2=[C:7]([C:5]([O:4][CH:1]([CH3:2])[CH3:3])=[O:6])[CH:8]([CH3:28])[CH2:9][N:10]12

Participants

4

Reactant 2

HCID 674DimethylamineHCID 867455674-Nitrophenyl (7-Isopropoxycarbonyl-6-methyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene)acetate

Product 1

HCID 57271419HCID 57271419, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1.50 g of 4-nitrophenyl (7-isopropoxycarbonyl-6-methyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene)acetate, was added 40 ml of a 25% aqueous solution of dimethylamine and the mixture was stirred at room temperature for 3 days. 40 ml of water was added thereto and the precipitate thus formed was collected by filtration, washed with water and dissolved in chloroform. After drying and distilling off the solvent, the crude crystals thus obtained were recrystallized from a solvent mixture of ether and n-hexane. Thus 0.6 g of the title compound was obtained.

Workup

  1. customthe precipitate thus formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. dissolutiondissolved in chloroform
  5. customAfter drying
  6. distillationdistilling off the solvent
  7. customthe crude crystals thus obtained
  8. customwere recrystallized from a solvent mixture of ether and n-hexane

Sources & evidence

ORD record
ord-62dd0dd976584d1f8d41b8de28be302a
Source dataset
uspto-grants-1992_03
Patent number
US05098919

Reaction notes

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