反应详情

温度

55 °C

To a slurry of 2-cyanopyrimidine (50 g) in water (100 ml) at 2° C. was added a solution of sodium hydroxide (50 wt %, 45.6 g) in water (30 ml) with an exotherm to 50° C. The mixture was stirred at 55° C. for 2 h, ethanol (500 ml) was added and the mixture concentrated in vacuo to an oil. Ethanol (250 ml) was added and the mixture concentrated to a paste. Ethanol (250 ml) was added and the mixture stirred at 15-20° C. for 30 min. The precipitate was collected by vacuum filtration, washed with ethanol (100 ml) and dried in a 75° C. vacuum oven to afford 67.57 g of the title compound as a white solid.

1. concentrationthe mixture concentrated in vacuo to an oil
2. additionEthanol (250 ml) was added
3. concentrationthe mixture concentrated to a paste
4. additionEthanol (250 ml) was added
5. stirringthe mixture stirred at 15-20° C. for 30 min
6. filtrationThe precipitate was collected by vacuum filtration
7. washwashed with ethanol (100 ml)
8. customdried in a 75° C. vacuum oven