Water → 2-Cyclohexyl-2-hydroxymethyl-butan-1,3-diol

HRID 2372417Notes

Reaction equation

HRID 2372417 reaction equation
[CH:1]1([C:7]2([CH:15]([OH:17])[CH3:16])[CH2:12][O:11]C(C)(C)[O:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O>CO>[CH:1]1([C:7]([CH2:8][OH:9])([CH:15]([OH:17])[CH3:16])[CH2:12][OH:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 962WaterHCID 199043995-Cyclohexyl-2,2-dimethyl-5-(1-hydroxyethyl)-1,3-dioxane

Product 1

HCID 199043812-Cyclohexyl-2-hydroxymethyl-butan-1,3-diol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Cyclohexyl-2,2-dimethyl-5-(1-hydroxyethyl)-1,3-dioxane (1.5 g.) and Dowex 50×8-200 ion exchange resin (H+ form) (1.0 g.) in methanol (30 ml.) and water (10 ml.) was refluxed with stirring for six hours. The mixture was filtered and the filtrate was evaporated in vacuo. 2-Cyclohexyl-2-hydroxymethyl-butan-1,3-diol was obtained as a pale yellow oil (1.2 g.) and was used without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-784b861463b94f929ab0573b4b1ab33b
Source dataset
uspto-grants-1992_03
Patent number
US05098929

Reaction notes

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