HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → Tert-butyl (s)-1-((s)-1-((2s,4s)-4-azido-2-((r)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 1-Aminotetralin, (R)- | HCID 7058072 | — |
| Reactant | (2s,4s)-Methyl 4-azido-1-((s)-2-((s)-2-(tert-butoxycarbonyl(methyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylate | HCID 57661019 | — |
| Product | Tert-butyl (s)-1-((s)-1-((2s,4s)-4-azido-2-((r)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate | HCID 57661012 | — |
Reaction Steps
The title compound of Example 2 was treated with LiOH using the general procedure C to hydrolyze the methyl ester. The resulting acid was coupled to (R)-tetrahydro-1-naphthylamine using the general procedure D to prepare the title compound of Example 3. 1H NMR (CDCl3): consistent with proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642554B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-9a9965aafb904556af148d73b96fbf6d |
| Source note | uspto-grants-2014_02 |