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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2372423Generated: October 31, 2026

2-Ethyl-2-hydroxymethylbutan-1,3-diol → 3,3-Di-(hydroxymethyl)-1,1,1-trifluorohexan-2-ol

https://huagongshe.com/reaction/2372423

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Ethyl-2-hydroxymethylbutan-1,3-diolHCID 12930548—
ReactantDiethyl 2-n-propyl-2-trifluoroacetylmalonateHCID 15021952—
Product3,3-Di-(hydroxymethyl)-1,1,1-trifluorohexan-2-olHCID 15021953—

Reaction Steps

3,3-Di-(hydroxymethyl)-1,1,1-trifluoro-hexan-2-ol was prepared from diethyl 2-n-propyl-2-trifluoroacetylmalonate using the method described for the preparation of 2-ethyl-2-hydroxymethyl-butan-1,3-diol [example A(ii)].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05098929
Source datasetuspto-grants-1992_03
ORD IDord-d6765cb5eb5d44a4a0f9f5f2dde111b2
Source noteuspto-grants-1992_03