Carbon Dioxide → HCID 19904337, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg) in 4 ml of 3-chloropropanol was stirred at room temperature and under nitrogen for 45 minutes with 240 mg of a 1.6% solution of KOH in 3-chloropropanol. The reaction mixture was decomposed with excess dry ice while immersing the flask into a water bath at room temperature. It was then isolated on a silica gel plate using ether, which elutes the allyl alcohol to the top of the plate (the plate was developed several times), followed by a mixture of chloroform-methanol 9:1 which elutes the product. This procedure gives 75 mg (64%) of the desired product, having a melting point of 142°-145° C. (decomposition) and providing the following analysis:

Provenance & Evidence