Methyl iodide → HCID 20080581, compound

HRID 2372467Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([O:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)[CH:5]=[C:6]([C:8]2([OH:14])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1.[CH3:27]I>>[F:1][C:2]1[CH:3]=[C:4]([O:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)[CH:5]=[C:6]([C:8]2([O:14][CH3:27])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 20080587HCID 20080587, compound

Product 1

HCID 20080581HCID 20080581, compoundYield 98%

Procedure

Using the procedure described in Example 3, 4-[5-fluoro-3-(naphth-2-ylmethoxy)phenyl]-4-hydroxytetrahydropyran was reacted with methyl iodide to give 4-[5-fluoro-3-(naphth-2-ylmethoxy)phenyl]-4-methoxytetrahydropyran in 98% yield, m.p. 109°-111° C.

Sources & evidence

ORD record: ord-5f960f466e744a6f94757df0442d99e7
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05098930

Reaction notes

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