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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2372487Generated: October 30, 2026

4-(3-Hydroxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran → 4-[3-(7-Fluoronaphth-2-ylmethoxy)phenyl]-4-methoxy-2,6-dimethyltetrahydropyran

https://huagongshe.com/reaction/2372487

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(3-Hydroxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyranHCID 20080618—
Reactant2-(Bromomethyl)-7-fluoronaphthaleneHCID 23292295—
Product4-[3-(7-Fluoronaphth-2-ylmethoxy)phenyl]-4-methoxy-2,6-dimethyltetrahydropyranHCID 2008067298.5%

Reaction Steps

Using the procedure described in Example 5, 7-fluoro-2-bromomethylnaphthalene (0.265 g) was reacted with 4-(3-hydroxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran (0.225 g, less polar isomer) to give 4-[3-(7-fluoronaphth-2-ylmethoxy)phenyl]-4-methoxy-2,6-dimethyltetrahydropyran (0.37 g, 93%), as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05098930
Source datasetuspto-grants-1992_03
ORD IDord-03a408fc8b604e3091105a82a3d380d8
Source noteuspto-grants-1992_03