Methyl iodide → 4-(3-Benzyloxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran

HRID 2372489Notes

Reaction equation

HRID 2372489 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2([OH:23])[CH2:20][CH:19]([CH3:21])[O:18][CH:17]([CH3:22])[CH2:16]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24]I>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2([O:23][CH3:24])[CH2:20][CH:19]([CH3:21])[O:18][CH:17]([CH3:22])[CH2:16]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 200806044-(3-Benzyloxyphenyl)-4-hydroxy-2,6-dimethyltetrahydropyran

Product 1

HCID 200806304-(3-Benzyloxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran

Procedure

Using the procedure described in Example 3, the more polar isomer of 4-(3-benzyloxyphenyl)-4-hydroxy-2,6-dimethyltetrahydropyran (described in the portion of Example 52 which is concerned with the preparation of starting materials) was reacted with methyl iodide to give 4-(3-benzyloxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran, (77%, more polar isomer), as an oil.

Workup

  1. customis concerned with the preparation of starting materials)

Sources & evidence

ORD record
ord-dea038c639964fc283a87af66a63cc77
Source dataset
uspto-grants-1992_03
Patent number
US05098930

Reaction notes

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