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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2372490Generated: November 1, 2026

1-Bromo-6-(bromomethyl)naphthalene → 4-[3-(5-Bromonaphth-2-ylmethoxy)-5-fluorophenyl]-4-methoxytetrahydropyran

https://huagongshe.com/reaction/2372490

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-6-(bromomethyl)naphthaleneHCID 11324032—
Reactant3-Fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenolHCID 11736276—
Product4-[3-(5-Bromonaphth-2-ylmethoxy)-5-fluorophenyl]-4-methoxytetrahydropyranHCID 2008060952%

Reaction Steps

Using the procedure described in Example 5, 4-(5-fluoro-3-hydroxyphenyl)-4-methoxytetrahydropyran was reacted with 5-bromo-2-bromomethylnaphthalene to give 4-[3-(5-bromonaphth-2-ylmethoxy)-5-fluorophenyl]-4-methoxytetrahydropyran in 52% yield, as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05098930
Source datasetuspto-grants-1992_03
ORD IDord-92bc4782e36347599d975f154f97cca6
Source noteuspto-grants-1992_03