3-Fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenol → HCID 20080591, compound

HRID 2372492Notes

Reaction equation

HRID 2372492 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:16])[CH:5]=[C:6]([C:8]2([O:14][CH3:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1.Br[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][C:25]=2[C:29]([F:32])([F:31])[F:30])[CH:20]=1>>[F:1][C:2]1[CH:3]=[C:4]([O:16][CH2:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][C:25]=3[C:29]([F:30])([F:31])[F:32])[CH:20]=2)[CH:5]=[C:6]([C:8]2([O:14][CH3:15])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 117362763-Fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenolHCID 20080641HCID 20080641, compound

Product 1

HCID 20080591HCID 20080591, compoundYield 36%

Procedure

Using the procedure described in Example 5, 4-(5-fluoro-3-hydroxyphenyl)-4-methoxytetrahydropyran was reacted with 2-bromomethyl-5-trifluoromethylnaphthalene to give 4-[5-fluoro-3-(5-trifluoromethylnaphth-2-ylmethoxy)phenyl]-4-methoxytetrahydropyran in 36% yield, as an oil.

Sources & evidence

ORD record
ord-5d6ad7f2c10147b187d9b947338ad979
Source dataset
uspto-grants-1992_03
Patent number
US05098930

Reaction notes

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