Propanal → 4-(3-Benzyloxy-5-fluorophenyl)-2,4-diethyl-1,3-dioxolane

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Reaction Steps

Using the procedure described in Example 1, 2-(3-benzyloxy-5-fluorophenyl)butane-1,2-diol (1.02 g) was reacted with propionaldehyde (6 ml) in the presence of concentrated sulphuric acid (1 drop) to give 4-(3-benzyloxy-5-fluorophenyl)-2,4-diethyl-1,3-dioxolane, as an oil and as a mixture of diastereoisomers. The product so obtained was hydrogenolysed using the procedure described in the Portion of Example 6 which is concerned with the preparation of starting materials. There was thus obtained the required starting material (0.5 g, 60%), as an oil.

Provenance & Evidence