Acetone → HCID 19756589, compound

HRID 2372497Notes

Reaction equation

[C:1]1([C:7]#[C:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]([C:17]([OH:22])([CH2:20][CH3:21])[CH2:18][OH:19])[CH:14]=[N:15][CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:23][C:24]([CH3:26])=O>>[CH2:20]([C:17]1([C:13]2[CH:14]=[N:15][CH:16]=[C:11]([O:10][CH2:9][C:8]#[C:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:12]=2)[CH2:18][O:19][C:24]([CH3:26])([CH3:23])[O:22]1)[CH3:21]

Participants

Reactant 2

HCID 180Acetone

HCID 19756588HCID 19756588, compound

Product 1

HCID 19756589HCID 19756589, compoundYield 59%

Procedure

Using the procedure described in Example 1, 2-[5-(3-phenylprop-2-ynyloxy)pyrid-3-yl]butane-1,2-diol was reacted with acetone to give 4-ethyl-2,2-dimethy-4-[5-(3-phenylprop-2-ynyloxy)pyrid-3-yl]-1,3-dioxolane in 59% yield, as an oil.

Sources & evidence

ORD record: ord-faf4a927b5bd4cbba9e188990cf1eb2e
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05098932

Reaction notes

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