2-Amino-2-ethyl-1,3-propanediol → HCID 19904550, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-2-ethyl-1,3-propanediol (I-a) (297.9 grams, 2.50 moles) is charged to a reactor and heated to 70° C. under nitrogen. Then, 315.0 grams (2.50 moles) of 2,3-dimethylmaleic anhydride (DMMA) (II-a) is added portionwise with stirring to the reactor. The material is heated to a sufficient temperature (110°-130° C.) to drive off the water of condensation which is collected in a Dean-Stark trap. Once the theoretical amount of water is collected the product is isolated by vacuum distillation (167°-176° C. at 3 mm Hg). This product is used as an intermediate for the formation of polyurethanes and polyesters as will be described in succeeding examples.

Provenance & Evidence