Nicotinic Acid → HCID 23168157, compound

Participants

Reaction Steps

According to the present invention, 1,2-bis(nicotinamido)propane can be obtained by suspending nicotinic acid in an inert organic solvent and reacting nicotinic acid with an organic base and a condensing agent, and further with 1,2-propanediamine. The solvent is then removed from the resulting reaction solution to obtain crude 1,2-bis(nicotinamido)propane. The crude product is then reacted with a lower alcohol such as methanol and nitric acid to produce 1,2-bis(nicotinamido)propane dinitrate, and the resulting dinitrate salt is recrystallized from a mixture of water and a lower alcohol. The 1,2-bis(nicotinamido)propane dinitrate thus obtained was suspended in an organic solvent, and an alkali or a solution of alkali is added to the suspension. The organic layer containing the dissociated 1,2-bis(nicotinamido)propane was separated, the solvent is distilled off under reduced pressure, and the product is crystallized from a solvent and then purified by recrystallization to obtain 1,2-bis(nicotinamido)propane having a high purity.

Provenance & Evidence