Hydrochloric Acid → 4-(4-Hydroxy-3-nitro-phenyl)sulfonyl-2-nitro-phenol

Participants

Reaction Conditions

Reaction Steps

Into a 3-liter, 3-necked, round-bottom flask are charged 121 g of 3-nitro-4-hydroxyphenyl sulfone bis-methylcarbonate, 200 mL of methanol, 250 mL of water and 200 g of 50 percent aqueous sodium hydroxide. The reaction is heated to 55° C. for a period of 3 hours. Upon completion, the reaction is then cooled to 0° C. and acidified with concentrated hydrochloric acid. The resultant yellow solid is isolated by filtration, washed with water, and air dried to give 82 g of essentially pure 4-hydroxy-3-nitrophenyl sulfone (90 percent yield).

Provenance & Evidence