Nitrogen → HCID 14833063, compound

Participants

Reaction Conditions

Reaction Steps

All operations are carried out in an N2 atmosphere. 0.5 mol of cyanuric chloride is added to a mixture of 300 ml of acetone and 200 g of ice, and 0.25 mol of each of piperazine and Na2CO3 as 8% strength by weight and 20% strength by weight aqueous solutions respectively are added simultaneously. During this addition, the reaction temperature is maintained at between minus 15° C. and 0° C. and the pH is maintained at between 5 and 7. The reaction mixture is stirred for 30 minutes and filtered with suction, and the residue is washed with water and suspended in 0.2 1 of water. 1 mol of piperidine and 1.05 mol of NaOH as 30% strength by weight aqueous solutions are subsequently added simultaneously dropwise at room temperature, and the mixture is refluxed for 20 hours. The reaction mixture is filtered with suction, and the residue is washed with water and dried. A finely crystalline, white powder is obtained.

Provenance & Evidence