Ammonium formate → HCID 14199165, compound

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Reaction Steps

To a solution of 1-(4-methoxycarbonylphenyl)-2-nitro-butan-2-ol (0.34 g, 1.3 mmol) in THF (5 mL) and methanol (5 mL) was added 10% palladium on carbon (50 mg) followed by ammonium formate (0.4 g, 5 equivalents). The resulting mixture was stirred at room temperature for 3 hours ten diluted with Et2O, filtered and evaporated in vacuo. Flash column chromatography (SiO2, 15% MeOH in CHCl3) gave erythro 1-(4-methoxycarbonylphenyl)-2-amino-butan-1-ol (0.22 g, 73%).

Provenance & Evidence