N-carbobenzyloxyalanine → HCID 13132291, compound

HRID 2372584Notes

Reaction equation

HRID 2372584 reaction equation
Cl.C([O:4][C:5](=[O:18])[CH2:6][CH2:7][NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)C.C([NH:29][C@H:30]([C:32](O)=[O:33])[CH3:31])(OCC1C=CC=CC=1)=O>>[NH2:29][C@H:30]([C:32]([N:8]([CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)[CH2:7][CH2:6][C:5]([OH:4])=[O:18])=[O:33])[CH3:31]

Participants

3

Reactant 2

HCID 736104N-carbobenzyloxyalanineHCID 13132281HCID 13132281, compound

Product 1

HCID 13132291HCID 13132291, compoundYield 69.7%

Procedure

By reacting 7 g of N-(indan-2-yl)-β-alanine ethyl ester hydrochloride with 7 g of N-carbobenzoxy-L-alanine and treating the reaction mixture as in Reference Example 4, there is obtained 5 g of L-alanyl-N-(indan-2-yl)-β-alanine. Melting point 205°-206° C.

Workup

  1. additiontreating the reaction mixture as in Reference Example 4

Sources & evidence

ORD record
ord-60bbc61380434cddb58507d830b6464c
Source dataset
uspto-grants-1992_03
Patent number
US05098892

Reaction notes

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