N-carbobenzyloxyalanine → HCID 53966924, compound

HRID 2372586Notes

Reaction equation

HRID 2372586 reaction equation
Cl.C([O:4][C:5](=[O:17])[CH2:6][NH:7][CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)C.C([NH:28][C@H:29]([C:31](O)=[O:32])[CH3:30])(OCC1C=CC=CC=1)=O>>[NH2:28][C@H:29]([C:31]([N:7]([CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[CH2:6][C:5]([OH:4])=[O:17])=[O:32])[CH3:30]

Participants

3

Reactant 2

HCID 736104N-carbobenzyloxyalanineHCID 67915250HCID 67915250, compound

Product 1

HCID 53966924HCID 53966924, compoundYield 60%

Procedure

By reacting 13 g of (indan-1-yl)glycine ethyl ester hydrochloride with 11.6 g of N-carbobenzoxy-L-alanine and treating the reaction mixture as in Reference Example 4, there is obtained 8.0 g of L-alanyl-N-(indan-1-yl)glycine as colorless amorphous powder.

Workup

  1. additiontreating the reaction mixture as in Reference Example 4

Sources & evidence

ORD record
ord-203dd956b8944cc69a2d68c9c98a8557
Source dataset
uspto-grants-1992_03
Patent number
US05098892

Reaction notes

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