N-carbobenzyloxyalanine → HCID 54432872, compound

HRID 2372587Notes

Reaction equation

C([O:3][C:4](=[O:24])[CH2:5][NH:6][CH:7]1[C:15]2[C:10](=[CH:11][C:12]([O:16]CC3C=CC=CC=3)=[CH:13][CH:14]=2)[CH2:9][CH2:8]1)C.C([NH:35][C@H:36]([C:38](O)=[O:39])[CH3:37])(OCC1C=CC=CC=1)=O>>[NH2:35][C@H:36]([C:38]([N:6]([CH:7]1[C:15]2[C:10](=[CH:11][C:12]([OH:16])=[CH:13][CH:14]=2)[CH2:9][CH2:8]1)[CH2:5][C:4]([OH:3])=[O:24])=[O:39])[CH3:37]

Participants

Reactant 2

HCID 736104N-carbobenzyloxyalanine

HCID 19903121HCID 19903121, compound

Product 1

HCID 54432872HCID 54432872, compoundYield 60.8%

Procedure

By reacting 10 g of (5-benzyloxyindan-1-yl)glycine ethyl ester with 8 g of N-carbobenzoxy-L-alanine and treating the reaction mixture as in Reference Example 4, there is obtained 5.2 g of L-alanyl-N-(5-hydroxyindan-1-yl)glycine as colorless amorphous powder.

Workup

additiontreating the reaction mixture as in Reference Example 4

Sources & evidence

ORD record: ord-6f409042e45f442faa418a2831ad76cf
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05098892

Reaction notes

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