N-carbobenzyloxyalanine → HCID 67915247, compound

HRID 2372588Notes

Reaction equation

[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:7]([O:11][C:12](=[O:28])[CH2:13][NH:14][CH:15]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[CH2:17][CH2:16]1)([CH3:10])([CH3:9])[CH3:8].C([NH:39][C@H:40]([C:42](O)=[O:43])[CH3:41])(OCC1C=CC=CC=1)=O>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:7]([O:11][C:12](=[O:28])[CH2:13][N:14]([C:42](=[O:43])[C@H:40]([CH3:41])[NH2:39])[CH:15]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[CH2:17][CH2:16]1)([CH3:10])([CH3:9])[CH3:8]

Participants

Reactant 2

HCID 736104N-carbobenzyloxyalanine

HCID 13132300HCID 13132300, compound

Product 1

HCID 67915247HCID 67915247, compoundYield 48.5%

Procedure

By reacting 7 g of N-(5,6-dimethoxyindan-1-yl)glycine tert-butyl ester oxalate with 4.8 g of N-carbobenzoxy-L-alanine and treating the reaction mixture as in Reference Example 5, there is obtained 4 g of L-alanyl-N-(5,6-dimethoxy-indan-1-yl)glycine tert-butyl ester oxalate as colorless amorphous powder.

Workup

additiontreating the reaction mixture as in Reference Example 5

Sources & evidence

ORD record: ord-f66789fb022842888a1b96aa54eb1714
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05098892

Reaction notes

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