2-Chloropyridine → HCID 22418741, compound

HRID 2372604Notes

Reaction equation

HRID 2372604 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][NH:5][CH3:6].Cl[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1>>[CH3:1][NH:2][CH2:3][CH2:4][N:5]([CH3:6])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 79772-ChloropyridineHCID 8070N,N'-Dimethylethylenediamine

Product 1

HCID 22418741HCID 22418741, compound

Procedure

A mixture of N,N'-dimethylethylene-diamine (25 g) and 2-chloropyridine (1.3 g) is warmed at 85° with stirring for 18 h. The excess dimethylethylenediamine is removed by distillation at reduced pressure. The distillation residue is distributed between ethyl acetate (150 ml) and water (100 ml). The organic phase is separated, dried over sodium sulfate and the organic solvent removed under reduced pressure to give the title compound.

Workup

  1. temperatureis warmed at 85°
  2. customThe excess dimethylethylenediamine is removed by distillation at reduced pressure
  3. customThe organic phase is separated
  4. dry with materialdried over sodium sulfate
  5. customthe organic solvent removed under reduced pressure

Sources & evidence

ORD record
ord-7245cdc0d6e648618615fe729f4f3bcf
Source dataset
uspto-grants-1992_03
Patent number
US05099019

Reaction notes

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