HCID 14878745, compound → HCID 15231176, compound

HRID 2372632Notes

Reaction equation

HRID 2372632 reaction equation
I[CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C:18](=[CH:19][CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:23])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[CH3:24].[N:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32]1[N:37]=[C:36]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=2)[N:35]=[C:34]([N:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[N:33]=1>>[CH3:24][C@@H:5]1[CH2:6][C@@H:7]2[C@:21]([CH3:22])([CH2:20][CH:19]=[C:18]3[C@H:8]2[CH2:9][CH2:10][C:11]2[C@:16]3([CH3:17])[CH:15]=[CH:14][C:13](=[O:23])[CH:12]=2)[C@H:4]1[C:3](=[O:25])[CH2:2][N:47]1[CH2:48][CH2:49][N:44]([C:34]2[N:35]=[C:36]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=3)[N:37]=[C:32]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][N:26]=3)[N:33]=2)[CH2:45][CH2:46]1

Participants

3

Reactant 2

HCID 14878745HCID 14878745, compoundHCID 15230685HCID 15230685, compound

Product 1

HCID 15231176HCID 15231176, compound

Procedure

Following the general procedure of EXAMPLES 1-6A. 7, 8, 11-19, 83 and 126, and making non-critical variations but starting with 21-iodo-16α-methylpregna-1,4,9(11)-triene-3,20-dione (PREPARATION S-22) and 4-[4,6-bis(2-pyridinyl)-1,3,5-triazin-2-yl]piperazine (PREPARATION A-49) the title compound is obtained. EXAMPLE 138 16α-Methyl-21-[4-[5,6-bis(2-pyridinyl)-1.2.4-triazin. 3-yl]-1-piperazinyl]pregna-1,4,9(11)-triene-3,20-dione (I)

Sources & evidence

ORD record
ord-219da61266794804b3d01e186f4baf1a
Source dataset
uspto-grants-1992_03
Patent number
US05099019

Reaction notes

Loading…