Hydrochloric Acid → HCID 19901325, compound

Participants

Reaction Conditions

Reaction Steps

Methyl phenyl sulphone (12.5 g, 0.08 mole) dissolved in THF (150 cc) is added at ambient temperature to a molar solution (100 cc) of ethylmagnesium bromide. The mixture is stirred for 1 h and then cooled to -50° C. 2-Chloroacetophenone (12.5 g, 0.08 mole) dissolved in THF (150 cc) is run in and stirred for 2 h at -20° C. The mixture is poured into normal hydrochloric acid (200 cc) and ammonium chloride (6 g). It is reextracted with ether (3×50 cc), washed until neutral and dried over MgSO4. The crude is precipitated with heptane and recrystallized from isopropyl ether to give flocculent white crystals of 1-chloro-2-phenyl-3-phenylsulphonyl-2-propanol (6.5 g, 26%). Mp=110° C.

Provenance & Evidence