Acetic Acid → HCID 14580198, compound

Participants

Reaction Conditions

Reaction Steps

In a manner identical with Example 57, 2,3'-dibromoacetophenone (7.8 g, 0.028 mole) is treated with 1 equivalent of the magnesium anion of methyl phenyl sulphone in THF at -70° C. The mixture is stirred for 2 h at -70° C., acetic acid (7 cc) is then added and the mixture is poured into water (100 g). It is reextracted with ether (3×100 cc), is washed with brine (2×100 cc) and is dried over MgSO4. The crude is precipitated with ether (50 cc) with warming and recrystallized from isopropyl ether to give white crystals of 1-bromo-2-[3'-bromophenyl]-3-phenylsulphonyl-2-propanol (2.4 g, 20%). Mp=132° C.

Provenance & Evidence